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Proposed pathomechanism of ALS in axon compartments. (1) Neuronal cytoskeleton; (2) cargo transport within axons; (3) axonal energy supply; (4) clearance of junk protein; (5) Neuromuscular junction (NMJs); (6) aberrant axonal branching; (7) Axonal translation; (8) Intra-axonal transcription factors are prominent features of the proposed pathomechanism.
