Figure 2.
High-Fat Diet-Induced Obesity Reshapes Visceral Adipose Tissue Derived-MHC Class I-Associated Immunopeptidome (MIP)
(A)The Venn diagrams represent the overlap analysis of VAT MIPs and their potential source proteins comparing NCD-fed (lean) and HFD-fed (obese) mice, respectively. Numbers indicate the number of identified peptides or their potential source proteins that were shared between or unique to each MIP.
(B) The top 10 GO enrichment terms of shared or exclusive MIP potential source proteins identified in HFD and NCD VAT. The three GO categories include biological process (BP), molecular function (MF), and cellular component (CC). The x- and y axes represent the protein number of corresponding GO terms and the GO terms, respectively.
(C) KEGG pathway enrichment analysis of shared or exclusive MIP potential source proteins identified in HFD and NCD VAT. The horizontal axis indicates the ratio of the number of identified proteins versus the total number of proteins in the same KEGG pathway, and the vertical ordinates represent the terms of the KEGG pathways. The bubble size indicates the number of proteins matched in the KEGG pathway. The color represents −log2 (p value): Logarithmic conversion of Fisher exact test p value.