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. 2019 Mar 22;10(2):132–140. doi: 10.1016/j.jtcme.2019.03.006

Fig. 5.

Fig. 5

Effects of M. alba stem extract (MSE), oxyresveratrol (OXY), glucosamine sulfate (GS) and diclofenac sodium (DCS) on IL-1β-induced MMP-13 production in the C28/I2 human chondrocyte cell line. The cells were untreated (Bar 1), only stimulated with IL-1β 10 ng/mL (Bar 2) and pretreated with MSE, OXY, GS and DCS for 2 h and then stimulated by IL-1β 10 ng/mL for 22 h. The cell culture supernatant was collected and determined by ELISA. The concentration of MMP-13 was normalized to the activated control. The data are expressed as mean ± S.D. of three independent experiments. *p < 0.05 and **p < 0.01 compared to the IL-1β-stimulated cells.