Table 2.
Comparisons of frequencies of microcytosis (mean corpuscular volume or MCV < 80 fL), macrocytosis (MCV ≥ 100 fL), blood hemoglobin (Hb) and serum iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and gastric parietal cell antibody (GPCA) positivity between 42 burning mouth syndrome (BMS) patients with vitamin B12 deficiency (B12D/BMS patients) and 442 healthy control subjects.
| Group | Patient number (%) |
|||||||
|---|---|---|---|---|---|---|---|---|
| Microcytosis (MCV < 80 fL) | Macrocytosis (MCV ≥ 100 fL) | Hb deficiency (Men < 13 g/dL, women < 12 g/dL) | Iron deficiency (<60 μg/dL) | Vitamin B12 deficiency (<200 pg/mL) | Folic acid deficiency (<4 ng/mL) | Hyperhomocysteinemia (>12.3 μM) | GPCA positivity | |
| B12D/BMS patients (n = 42) | 3 (7.1) | 22 (52.4) | 26 (61.9) | 11 (26.2) | 42 (100.0) | 0 (0.0) | 35 (83.3) | 18 (42.9) |
| aP-value | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | NA | <0.001 | <0.001 |
| Healthy control subjects (n = 442) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 11 (2.5) | 8 (1.8) |
NA = not assessed.
a
Comparisons of frequencies of parameters between 42 B12D/BMS patients and 442 healthy control subjects by chi-square test.