Table 1. Description of study designs and reported norovirus induced transaminitis.

Study reference	Year of Publication	Country	Study design	Age group studied (years)	Data collection methods	Diagnostic method for norovirus	Timing between norovirus infection and hepatitis/transaminitis	Definition of hepatitis	Excluded other hepatotrophic causes (Y/N)
Nakajima H et al. [6]	2012	Japan (Tokyo)	Case Report	48	Retrospective routine laboratory investigations.	Detected by viral antigen check and confirmed by reverse transcription PCR.	Same day	Elevated LFTs	Y
Zenda T et al. [11]	2011	Japan (Ishikawa)	Case Report	56	Retrospective routine laboratory investigations.	Positive test for norovirus antigens in stool using immunochromatographic assay kits.	Same day	Elevated LFTs	Y
Kucuk O et al. [10]	2016	Turkey (Istanbul)	Retrospective hospital-based	0 to 17	Retrospective study from 2010 and 2013 of acute viral gastroenteritis.	Rapid antigen tests and PCR.	N/A	Elevated LFTs	Y
Tsuge et al. [12]	2010	Japan (Okayama)	Case series	1 to 7	Prospective study measuring LFTs and bloods in children presenting with gastroenteritis.	RT-PCR assay	Case 1: 5 days Case 2: 1 day Case 3: 6 days Case 4: 11 days	Elevated LFTs	Y
Khayat AA et al. [13]	2019	USA (Wisconsin)	Case series	3 and 8	Retrospective routine laboratory investigations.	Stool specimens for norovirus antigens.	Case 1 and 2: Same day	Elevated LFTs	Y

Notes: Abbreviations: FBC, full blood count; LFT, liver function test; USA, United States of America; PCR, polymerase chain reaction; RT-PCR, reverse transcription-polymerase chain reaction.