Table 3.

Comparison of baseline characteristics and diagnostic value of ROC curves of various combined detection.

Combined detection	AUC	Sensitivity (%)	Specificity (%)	95% CI	PPV (%)	NPV (%)
Two-item in combination
QFT + ESR	0.804	76.71	77.04	0.745-0.863	64.4	86.0
QFT + serum ADA	0.823	90.41	69.63	0.767-0.879	61.7	93.1
QFT + serum CA125	0.830	76.71	81.48	0.774-0.886	69.1	86.6
QFT + hs − CRP	0.844	83.56	78.52	0.789-0.898	67.8	89.8
Three-item in combination
QFT + ESR + serum ADA	0.816	87.67	68.15	0.759-0.873	59.8	91.1
QFT + ESR + serum CA125	0.814	90.41	63.70	0.758-0.871	57.4	92.5
QFT + ESR + hs − CRP	0.840	87.67	74.81	0.785-0.894	65.3	91.8
QFT + serum ADA + serum CA125	0.823	89.04	71.11	0.767-0.879	62.5	92.3
QFT + serum ADA + hs − CRP	0.858	95.89	64.44	0.808-0.908	59.3	96.7
QFT + serum CA125 + hs − CRP	0.851	91.78	70.37	0.798-0.904	62.6	94.1
Four-item in combination
QFT + ESR + serum ADA + serum CA125	0.819	83.56	69.63	0.763-0.875	59.8	88.7
QFT + ESR + serum ADA + hs − CRP	0.857	91.78	69.63	0.807-0.908	62.0	94.0
QFT + serum ADA + serum CA125 + hs − CRP	0.858	83.56	76.30	0.807-0.908	65.6	89.6
QFT + ESR + serum CA125 + hs − CRP	0.849	84.93	76.30	0.796-0.901	66.0	90.4
Five-item in combination
QFT + ESR + serum ADA + serum CA125 + hs − CRP	0.859	97.26	62.96	0.809-0.909	58.7	97.7

Note: Comparison of AUCs of two-item in combination, p > 0.05; comparison of AUCs of three-item in combination, p > 0.05; comparison of AUCs of four-item in combination, p > 0.05. PPV: positive predictive value; NPV: negative predictive value; AUC: area under the curve; QFT: Quanti FERON-TB; ESR: erythrocyte sedimentation rate; ADA: adenosine deaminase; CA125: cancer antigen 125; hs-CRP: high-sensitivity C-reactive protein.