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. 2020 Mar 20;2020:9415082. doi: 10.1155/2020/9415082

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Copyright © 2020 Tai-Yuan Chuang et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Oral treatment with the herbal formula B307 (CHM) effectively alleviated hypothyroidism-induced increase of reactive oxygen species (ROS) in the blood of TD rats. (a) Change of average blood ROS over time among sham, CHM, TD, and TD + CHM rats. (b) Statistical comparison of quantified levels of total blood ROS among sham, CHM, TD, and TD + CHM rats. Blood ROS levels of TD rats was significantly higher than those of sham rats but significantly lower those TD rats who underwent CHM treatment. The results are shown as mean ± SEM (^∗∗P < 0.01, N = 5 for each group, two-way ANOVA followed by Student–Newman–Keuls multiple comparison posttest).