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. 2020 Mar 20;2020:7812709. doi: 10.1155/2020/7812709

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Copyright © 2020 Jiawei Liao et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Inhibition of UBA1 decreased proinflammatory cytokine levels in diet-induced atherosclerosis in Apoe-/- mice. (a) Flow cytometry analysis of circulating monocytes, neutrophils, and T cells. (b) Quantitative real-time PCR analysis of aortic expression of cytokines associated with monocyte recruitment (Mcp-1, Vcam-1, and Icam-1). (c) Quantitative real-time PCR analysis of aortic expression of macrophage-derived proinflammatory (Il-1β, Il-6, and Tnfα) and anti-inflammatory (Il-4 and Il-10) cytokines. n = 5‐6 per group; ∗: <0.05; ns: not significant.