Table 2.
TERT, OGG1, and CHRNA5 genotypes and lung cancer risk.
| Genes | Genotype/modea | Cases (%) | Controls (%) | p | OR∗ (CI) | p ∗ |
|---|---|---|---|---|---|---|
| TERT rs2853669 | 126 | 94 | ||||
| TT | 71 (56.3) | 57 (61) | Ref | — | — | |
| TC | 49 (38.9) | 36 (38) | 0.755 | 0.99 (0.53–1.89) | 0.99 | |
| CC | 6 (4,8) | 1 (1) | 0.11 | 4.15 (0.61–83.73) | 0.21 | |
| T | 191 (76) | 150 (80) | Ref | — | — | |
| C | 61 (24) | 38 (20) | 1.22 (0.72–2.07) | 0.45 | ||
| Recessive | 0.12 | 4.72 (0.68–97.04) | 0.17 | |||
| Dominant | 0.52 | 1.11 (0.59–2.07) | 0.75 | |||
|
| ||||||
| CHRNA5b rs16969968 | 143 | 211 | ||||
| GG | 60 (42) | 93 (44.3) | Ref | — | — | |
| GA | 64 (44.8) | 105 (49.8) | 0.8 | 0.98 (0.58–1.63) | 0.93 | |
| AA | 19 (13.2) | 13 (6.2) | 0.03 | 1.75 (0.68–4.69) | 0.25 | |
| G | 184 (64.3) | 291 (69) | Ref | — | — | |
| A | 102 (35.7) | 131 (31) | 1.16 (0.80–1.68) | 0.41 | ||
| Recessive | 0.02 | 1.83 (0.78–4.48) | 0.16 | |||
| Dominant | 0.69 | 1.07 (0.65–1.76) | 0.78 | |||
|
| ||||||
| OGG1b rs1052133 | 144 | 210 | ||||
| CC | 79 (54.9) | 107 (50.9) | Ref | — | — | |
| CG | 54 (37.5) | 83 (39.3) | 0.58 | 0.88 (0.52–1.48) | 0.62 | |
| GG | 11 (7.6) | 20 (9.5) | 0.46 | 1.45 (0.53–4.07) | 0.46 | |
| C | 212 (73.6) | 297 (71) | Ref | — | — | |
| G | 76 (26.4) | 123 (29) | 1.01 (0.68–1.5) | 0.92 | ||
| Recessive | 0.53 | 1.44 (0.55–3.83) | 0.45 | |||
| Dominant | 0.46 | 0.94 (0.57–1.54) | 0.79 | |||
OR = odds ratio; CI = confidence interval. ∗OR adjusted for sex age and tobacco consumption. aThe dominant mode: AA vs Aa+aa, where A is major allele and a is minor allele; the recessive mode: AA+Aa vs aa. bNumbers may not add up total number of patients due to genotype failures.