Table 3.
Scaffold-based transplantation
|
Donor |
Recipients (strain) | Outcomes | Year | ||
| Scaffold | Species | Seeding cell | |||
| Decellularized organ liver | Human | Mouse (C57BL/6J) | Immunogenicity | 2015[2] | |
| Porcine | Rat (F344) | Immunogenicity | 2013[86] | ||
| Porcine | Immunogenicity | 2013[87] | |||
| Porcine | Engraftment | 2012[88] | |||
| Sheep, rat | Sheep, rat | Engraftment | 2015[89] | ||
| Rat | Hepatocytes (rat), BM- MSCs (Rat) | Rat (Lewis) | Engraftment | 2014[90] | |
| Hepatocytes (rat) | Rat (Lewis) | Engraftment, Hepatic function | 2010[91], 2011[92] | ||
| Mouse | Hematopoietic progenitor cells (mouse) | Mouse (C57Bl/6) | Hepatic function, metabolic function | 2018 [93] | |
| BM-MSCs (mouse) | Mouse (NOD-SCID) | Survival extension, hepatic function | 2014[94] | ||
| Placenta | Human | Liver cells (sheep) | Sheep | Survival extension, hepatic function | 2018[15] |
| Amniotic membrane | Human | AD-MSCs (human) | Mouse | Survival extension, hepatic function | 2015[95] |
| Nonwoven polyglycolic acid scaffolds | Liver cells (human, mouse) | Mouse (NOD/SCID) | Analysis of human metabolite | 2017[19] | |
| 3D hydrogel | Hepatocytes (human) | Mouse (nude) | Engraftment, hepatic function | 2016[16] | |
| Hyaluronan tube | Hepatocytes (rat), adipose-MSCs (human) | Rat (nude) | Engraftment, hepatic function | 2016[17] | |
| Polyethylene glycol hydrogels | Hepatocytes (rat) | Mouse (Nude) | Engraftment | 2015[20] | |
| Microbeads | Hepatocytes (rat) | Rat (SD) | Hepatic function | 2014 [96] | |
| Poly-L-glycolic acid | Hepatocytes (mouse) | Mouse (NOD/SCID) | Engraftment | 2014[21] | |
| Hyaluronan hydrogels | Hepatic stem cells (human) | Mouse (Athymic nude) | Engraftment | 2013[97] | |
| Apatite-fiber scaffold | Hepatocytes (mouse) + HSC + SECs | Mouse (BALB/CA nu) | Hepatic function | 2011[98] | |
| Chitosan-alginate fibrous scaffolds | BM-MSCs (human) | Rat (Wistar) | Hepatic function | 2010[99] | |
| Hyaluronic acid sponge | Fetal hepatocyte (rat) | Rat (LEC) | Engraftment, hepatic function | 2010[18] | |
3D: Three dimensional; SD: Sprague dawley; HSCs: Hematopoietic stem cells; BM-MSCs: Bone marrow derived mesenchymal stem cells.