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A model depicting the role of the RNF20/40 complex-dependent H2B ubiquitination in pre-mRNA processing. p53 recognizes p21 promoter and recruits RNF20/40 to gene transcription sites for H2B ubiquitination. PRPF8, a subunit of spliceosome, recognizes ubH2B via the C-terminal UBM. UbH2B mediates the recruitment of PRPF8 for pre-mRNA processing of p21.
