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. 2019 May 8;12(2):125–137. doi: 10.1093/jmcb/mjz032

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© The Author(s) (2019). Published by Oxford University Press on behalf of Journal of Molecular Cell Biology, IBCB, SIBS, CAS.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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GSK-J4 inhibits oxaliplatin-induced NOTCH2 expression. (A) Heatmap shows the expression profiles of variably expressed genes across control, oxaliplatin (50 μM)-treated, and GSK-J4 (1 μM)-treated cells. (B and C) Detection of GSK-J4 (1 μM) or oxaliplatin (50 μM)-induced changes in KDM genes (B) or NOTCH-related genes (C). (D) Venn diagram indicates oxaliplatin-upregulated and GSK-J4-downregulated genes. (E) Western blot detection of NOTCH2 expression after oxaliplatin (50 μM) and GSK-J4 (1 μM) treatment.