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. 2020 Mar 17;22(3):e17921. doi: 10.2196/17921

Table 2.

Health resources and quantification.

Domain Item Valuation
Direct medical costs


Inpatient care/day admission Days in hospital, rehabilitation, and nursing wards Standardized cost units

Ambulant consultations Visits to general practitioners, neurologists, others specialists (urologists, ophthalmologists, and psychiatrists), multiple sclerosis nurses, physical therapists, psychologists, occupational therapists, opticians, speech therapists, acupuncturists, and other alternative healing professionals Standardized cost units

Investigations/diagnostics Magnetic resonance imaging, computed tomography, spinal tap, blood tests, and others Physicians’ fee schedule

Over-the-counter medication Medication and recommending doctor Patient reported

Disease-modifying therapies
Annual therapy costs as calculated from medication reports

Home help and support of professionals Professional help, household care, and personal assistance Human capital approach

Medical consumables Medical consumables Patient reported
Direct nonmedical costs


Investments and equipment House and car modifications, walking aids, wheelchair (manual and electric), scooter, sickbed, and others; payer and grants Patient reported

Informal care Time taken for preparation of meals, climbing stairs, personal care, drug administration, transport, and others; reduction of working hours of relatives Opportunity costs method
Indirect costs


Employment and labor productivity Full or part time work, sick leaves, reduced working time, change of work, and loss of earning Human capital approach

Employment and labor productivity Absence hours (multiple sclerosis and others), total working hours, and productivity scale Human capital approach