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. 2020 Mar 17;22(3):e17921. doi: 10.2196/17921

Table 6.

Known-group analysis: health resource utilization costs of patients with multiple sclerosis per quarter by disability (N=2059).

Parameter EDSSa 0-1.0 (n=562) EDSS 1.5-2.5 (n=756) EDSS 3.0-4.0 (n=589) EDSS 4.5-5.5 (n=152)

Mean SD Median Mean SD Median Mean SD Median Mean SD Median
Total cost (€) 1099 2211 150 2295 3647 585 3112 3979 1334 4733 4639 4158
Direct medical cost (€)b 309 910 99 541 1724 165 789 1998 249 1003 2295 411
Direct nonmedical cost (€) 12 108 0 20 154 0 45 152 0 158 428 0
Indirect cost (€) 777 1822 0 1734 2820 0 2280 3178 127 3572 3572 3637

aEDSS: Expanded Disability Status Score.

bDisease-modifying therapies are not included in direct medical cost.