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Frequency of colony development following combination selection
| Compound | VX-950 (0 μM) | VX-950 (1.25 μM) | VX-950 (2.5 μM) |
|---|---|---|---|
| LCTA-949 (0 μM) | 100 | 90 | 20 |
| LCTA-949 (10 μM) | 100 | 20 | 0.0006 |
| LCTA-949 (20 μM) | 0.0002 | 0 | 0 |
| LCTA-1707 (10 μM) | 100 | 15 | 0.0004 |
| LCTA-1707 (20 μM) | 0.0002 | 0 | 0 |
Frequency was determined as number of colonies following 2 weeks of selection (third passage)/initial number of cells × 100.
Data are mean values for two to four independent experiments.
