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. 2016 Mar 19;145(4):486–496. doi: 10.1093/ajcp/aqw021

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© American Society for Clinical Pathology, 2016. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

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Myoinvasive endometrial adenocarcinoma, endometrioid type, in a background of adenomyosis, scanning (A, C, and E; ×5) and ×30 (B, D, and F) views. A and B, Myometrial invasion is present on the left side of the tissue section, characterized by packed neoplastic glands dissecting myometrium in a pushing/expansile pattern (H&E).

C and D, By immunohistochemistry, interferon-induced transmembrane protein 1 is negative around myoinvasive carcinoma, showing expression only in stroma of the endometrium and adenomyosis. E and F, CD10 immunohistochemistry shows strong and diffuse staining around both invasive and noninvasive carcinoma.

Myoinvasive endometrial adenocarcinoma, endometrioid type, in a background of adenomyosis, scanning (A, C, and E; ×5) and ×30 (B, D, and F) views. A and B, Myometrial invasion is present on the left side of the tissue section, characterized by packed neoplastic glands dissecting myometrium in a pushing/expansile pattern (H&E).

C and D, By immunohistochemistry, interferon-induced transmembrane protein 1 is negative around myoinvasive carcinoma, showing expression only in stroma of the endometrium and adenomyosis. E and F, CD10 immunohistochemistry shows strong and diffuse staining around both invasive and noninvasive carcinoma.