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. 2015 Jun 24;102(2):359–367. doi: 10.3945/ajcn.114.104216

TABLE 2.

DAVID functional annotation clusters generated from the list of proteins differentially expressed in human duodenal mucosa after 5 h of protein infusion

Annotation category Term Enrichment score1 Protein count P value2 Benjamini3 Related genes4
Annotation cluster 1
 PANTHER_MF_ALL MF00077: chaperone 2.09 4 0.0018 0.066 CCT4, HSPA9, HSP90AA1, YWHAE
 SP_PIR_KEYWORDS Chaperone 3 0.013 0.14 CCT4, HSPA9, HSP90AA1
Annotation cluster 2
 SP_PIR_KEYWORDS Actin binding 1.90 3 0.00086 0.011 EZN, MSN, PLS1
 PANTHER_BP_ALL BP00286: cell structure 6 0.0023 0.096 ACTB, EZN, LMNB1, MSN, PLS1, VIM
 PANTHER_MF_ALL MF00091: cytoskeletal protein 6 0.0052 0.097 ACTB, EZN, LMNB1, MSN, PLS1, VIM
 PANTHER_MF_ALL MF00261: actin binding cytoskeletal protein 4 0.015 0.14 ACTB, EZN, MSN, PLS1
Annotation cluster 3
 SP_PIR_KEYWORDS Protein biosynthesis 1.87 5 0.000046 0.00086 EEF1D, EEF2, EIF3F, EPRS, QARS
 REACTOME_PATHWAY REACT_17015: metabolism of proteins 5 0.0037 0.033 ACTB, CCT4, EEF1D, EEF2, EIF3F
 PANTHER_MF_ALL MF00071: translation factor 3 0.0093 0.11 EEF1D, EEF2, EIF3F
1

Fold enrichment of the cluster.

2

P value from the modified Fisher’s exact test (Expression Analysis Systematic Explorer score).

3

P value adjusted for multiple testing according to the Benjamini-Hochberg model.

4

Genes encoding the differentially expressed proteins in human: ACTB, actin, β CCT4, chaperonin containing TCP1, subunit 4 (δ); EEF1D, eukaryotic translation elongation factor 1δ EEF2, eukaryotic translation elongation factor 2; EIF3F, eukaryotic translation initiation factor 3, subunit F; EPRS, glutamyl-prolyl–transfer RNA synthetase; EZN, ezrin; HSPA9, heat shock 70-kDa protein 9; HSP90AA1, heat shock protein 90-kDa α; LMNB1, lamin B1; MSN, moesin; PLS1, plastin 1; QARS, glutaminyl–transfer RNA synthetase; VIM, vimentin; YWHAE, 14-3-3 protein ɛ.