Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jul 9;105(4):987–9998. doi: 10.3324/haematol.2018.214379

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright© 2020 Ferrata Storti Foundation

Material published in Haematologica is covered by copyright. All rights are reserved to the Ferrata Storti Foundation. Use of published material is allowed under the following terms and conditions:

https://creativecommons.org/licenses/by-nc/4.0/legalcode. Copies of published material are allowed for personal or internal use. Sharing published material for non-commercial purposes is subject to the following conditions:

https://creativecommons.org/licenses/by-nc/4.0/legalcode, sect. 3. Reproducing and sharing published material for commercial purposes is not allowed without permission in writing from the publisher.

PMC Copyright notice

Figure 1. — Mesenchymal stromal cells (MSC) from heathy donors (HD) or from acute myeloid leukemia (AML) patients confer a better survival to leukemia blasts, even in the presence of chemotherapy agents. (A, left) Histogram representing the number of living AML blasts after a 3-day culture without MSC [median 51,655 (56,830)] or with MSC from HD [median 91,815 (94,556)] or AML patients [median 56,896 (102,863)]. (Right) The same conditions but in the presence of 50nM of mitoxantrone. Culture conditions in the presence of the different types of MSC confer a significantly improved survival to AML blasts (left: ***P=0.0004; right: ***P=0.0003, n>10, represents the number of AML blasts/MSC donor combinations). (B) Histogram showing fluorescence intensity of AML blasts stained with mitoxantrone after a 3-day culture with or without MSC from HD (one representative experiment of the 6 performed). Control (CT) represents non-stained blasts. (C) Mitoxantrone mean fluorescence intensity (MFI) in AML blasts cultivated [median 2,191 (2,032)] or not [median 3,676 (3,546)] on HD MSC (**P=0.01, n=6, Wilcoxon test). (D) Mitoxantrone MFI in AML blasts cultivated [median 3,861 (1,147)] or not [median 1,821 (460)] on AML MSC (**P=0.01, n=3-9, Wilcoxon test). n: number. **P<0.01; ***P<0.001.