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. 2019 Jul 9;105(4):1129–1137. doi: 10.3324/haematol.2018.210583

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Figure 4. — Injection of factor VIII-encoding mRNA corrects acute bleeding in factor VIII-deficient mice. Factor VIII (FVIII)-deficient mice were injected intravenously with 3 μg of FVIII-encoding mRNA (empty squares) formulated in TransIT^®, with 1.2 IU (empty circles) or 3 IU (full diamonds) recombinant B domain-deleted-FVIII (rFVIII) or with phosphate-buffered saline (PBS) (full triangles). Mice tails were clipped 3 mm from the tip, 24 h after mRNA and PBS injection, or 30 min after rFVIII injection. Bleeding intensity was measured as the volume of blood lost during 20 min. Horizontal bars represent means and individual dots represent individual mice. Statistical differences were assessed using the double-sided Mann-Whitney test (ns: non-significant; *P<0.05; ***P<0.001).