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. 2019 Jul 4;105(4):1095–1106. doi: 10.3324/haematol.2018.214460

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Figure 6. — Increased cytosolic calcium as a result of downsizing: computer systems biology simulation of calcium signaling in normal and Wiskott-Aldrich syndrome platelets. Wiskott-Aldrich syndrome (WAS) platelets were assumed to have the same content of signaling proteins, scaled to the respective volume of compartments. (A, B) Stochastic simulation of the activation of normal platelets containing two (A) or four (B) mitochondria with 10 nM thrombin. With the collapse of one mitochondrion the average cytosolic calcium increases 1.5-fold (A) in the case of two mitochondria or does not change (B) in the case of four mitochondria. (C-E) Stochastic and deterministic simulations of normal and WAS platelets stimulated with 1 nM thrombin.