Figure 1.

Course of platelet counts in nine patients with cyclic thrombocytopenia. Splenectomy (SE) (patients 2, 3, 4, 5 and 7) and treatment with a thrombopoietin receptor agonist (TPRA) (patients 1, 2 and 3) were ineffective. A durable remission was seen in six patients. In three patients the increase in platelet count was in association with cyclosporine A (CsA). Rituximab (R) treatment was followed by an increase in the platelet count in one (patient 4). One female each suffered from intracranial bleeding (ICB) (patient 1) or pulmonary embolism (PE) (patient 3). All patients were treated with corticosteroids without effect. Time of evaluation of cycle duration is indicated by a bar underneath the x-axis.