Table 4.
Putative protein cleavage of the HCoV‐NL63 1a/1b polyprotein
| Protein | Cleavage site | Processing enzyme |
|---|---|---|
| nsp1 | FGHGAG|SVVFVD | PLpro |
| nsp2 | FTKLAG|GKISFS | PLpro |
| nsp3; PLpro | VAKQGA|GFKRTY | PLpro |
| nsp4 | YNSTLQ|SGLKKM | Mpro |
| nsp5; Mpro | YGVNLQ|SGKVIF | Mpro |
| nsp6 | KISTVQ|SKLTDL | Mpro |
| nsp7 | NSSTLQ|SVASSF | Mpro |
| nsp8 | RVVKLQ|NNEIMP | Mpro |
| nsp9 | ATIRLQ|AGKQTE | Mpro |
| nsp10 | DRTTIQ|SVDISY | Mpro |
| nsp12; RdRp | NSTILQ|AAGLCV | Mpro |
| nsp13; MBD NTPase Helicase | KHADLH|SSQVCG | Mpro |
| nsp14; ExoN | IETNLQ|SLENIA | Mpro |
| nsp15; NendoU | FYPQLQ|SAEWKC | Mpro |
| nsp16; 2′‐O‐MT | – | – |
HCoV, human coronavirus; nsp, nonstructural protein; PLpro, papain‐like proteinase; Mpro, main proteinase.