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Enzymatic activities of the wild type and site-directed mutants for SARS-CoV 3CLpro.a
| Protein | Proteolytic activity (%) |
|---|---|
| WT SARS-CoV 3CLpro | 100 |
| SARS-CoV 3CLpro Ser1Ala | 46 |
| SARS-CoV 3CLpro Phe3Ala | 5 |
| SARS-CoV 3CLpro Arg4Ala | 10 |
| SARS-CoV 3CLpro Ser10Ala | <1 |
| SARS-CoV 3CLpro Glu14Ala | 4 |
| SARS-CoV 3CLpro Ser139Ala | 58 |
| SARS-CoV 3CLpro Phe140Ala | <1 |
aEnzymatic activities were averages determined in three parallel experiments. The activity of wild type SARS-CoV 3CLpro was taken as 100%.
