Figure 5.

Survival of mice after intranasal challenge with Yersinia pestis CO92 after a single intramuscular administration of AdsecV. Mice were immunized intramuscularly with either saline (naive mice), the control vector AdNull (10¹¹ particle units [pu]), or AdsecV (10⁸, 10⁹, 10¹⁰, or 10¹¹ pu) (n=10 mice/group) and were challenged 4 weeks later by intranasal administration of 3×10³ cfu of Y. pestis CO92. Data are representative of results from 2 independent experiments. A Time course of survival after challenge. For the mice that received 10¹⁰ or 10¹¹ pu of AdsecV (n=10 mice), P<.05 and P<.005, respectively, compared with the 2 control groups. B Dose-dependent survival of mice immunized with AdsecV at day 15 after challenge