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. 2009 Dec 15;200(12):1870–1873. doi: 10.1086/648378

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© 2009 by the Infectious Diseases Society of America

This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

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Prophylactic efficacy of the monoclonal antibody CR6261 and oseltamivir against lethal challenge with 25 times the median lethal dose of either A/HongKong/156/97 (top panels) or A/WSN/33 (bottom panels). Groups of 8 mice received either a single intravenous injection of 15 mg/kg CR6261 one day before challenge or 10 mg/kg oseltamivir per os for 5 days starting 1 day before challenge. As controls, groups of 8 mice received an irrelevant isotype-matched control monoclonal antibody (15 mg/kg). Mice were monitored for 21 days or until death. A and D, Kaplan-Meier survival probability curves. B and E, Mean change in body weight per group, expressed as the percentage of baseline body weight. Error bars represent 95% confidence intervals. C and F, Median clinical scores per group, with interquartile ranges