Fig. 5.
Predicted effect of ΔSa_immob on the temperature sensitivity of a) Ka_virus_T and b) the number of host CD4+T cells, C.VT, with bound HIV virions in a system comprising Ctotal = 103 CD4+ host T cells in a 1 mm3 vol of blood with a challenge dose of 105 HIV virions. The values of ΔHa_receptor_T0 and ΔSa_receptor_T0 at T0 = 37 °C for specific HIV Env:CD4 binding are given in Table 4 with n = 3 Env:CD4 specific interactions and ΔCp = −5.02 kJ/mol/K (Table 3) for ΔSa_immob = −400 J/mol/K (dashed line), −337 J/mol/K (dash-dotted line), −285 J/mol/K (dotted line) and −240 J/mol/K (solid line). c) Effect of ΔSa_immob on C.VT predicted at temperatures of 10 °C (dashed line), 22 °C (dash-dotted line), 30 °C (dotted line) and 37 °C (solid line) with symbols representing outputs from model. For case study 4, more negative values of ΔSa_immob represent virions of increasing diameter. For case study 5, non-specific HIV attachment factor interactions prior to the specific HIV Env:CD4 interactions make ΔSa_immob less negative through realising entropy loss of ΔSa_non_specific in Eq. (19) (see text).