Table 2.
Histologic evaluation of heart tissue from the mice (C57BL/6J)
| Coronary arteritis | ||||
|---|---|---|---|---|
| n | Mild | Severe | Total | |
| One booster | ||||
| B+I+ | 3 | 6/120 (5%) | 0/120 (0%) | 6/120 (5%) |
| B+I− | 3 | 1/120 (0.8%) | 0/120 (0%) | 1/120 (0.8%) |
| B−I+ | 3 | 0/120 (0%) | 0/120 (0%) | 0/120 (0%) |
| Four boosters | ||||
| B+I+ | 5 | 19/200 (9.5%) a | 1/200 (0.5%) | 20/200 (10%) a |
| B+I− | 5 | 2/200 (1%) | 0/200 (0%) | 2/200 (1%) |
| B−I+ | 5 | 0/200 (0%) | 0/200 (0%) | 0/200 (0%) |
| B−I− | 5 | 0/200 (0%) | 0/200 (0%) | 0/200 (0%) |
| Anti‐PrxII | ||||
| B+P+ | 5 | 16/200 (8%) a | 0/200 (0%) | 16/200 (8%) a |
| B+P− | 5 | 0/200 (0%) | 0/200 (0%) | 0/200 (0%) |
| B−P+ | 5 | 1/200 (0.5%) | 0/200 (0%) | 1/200 (0.5%) |
| B−P− | 5 | 0/200 (0%) | 0/200 (0%) | 0/200 (0%) |
Data are expressed as the number of positive cases of arteritis per 200 fields.
One booster: an experimental primary inoculation followed by one cMI inoculation or its substitute.
Four boosters: an experimental primary inoculation followed by four cMI inoculations or their substitutes.
Anti‐PrxII: an experimental primary inoculation followed by administration of antiperoxiredoxin II antibody or its substitute.
B+, BCG administered; B−, saline administered as a substitute for BCG; I+, cMI administered; I−, saline administered as a substitute for cMI; P+, antiperoxiredoxin II antibody administered; P−, saline administered as a substitute for antiperoxiredoxin II antibody.
Significant difference from other groups.