Table 3.

Summary of Quantitative Trait Locus Locations.

Traita	Locusb	Group/Nc	Allelesd	p Valuee	Sf	Pos (cM)g	Pos (mb)	MGI
Hepatocellular carcinoma	D11Mit156m	All/873	B6: 6% C: 1%	.09		34	64	89041
Lymphoma	D1Mit206p	All/876	D2: 30% C3: 18%	.003	*	95.8	174	91585
Lymphoma	D4Mit84p	All/848	D2: 29% C3: 18%	.02	*	37.7	75	92920
Hemangiosarcoma or fibrosarcoma	D4Mit170p	All/842	C: 17% B6: 8%	.009	*	66.6	136	92798
Mammary adenocarcinoma	D4Mit55p	Multiparous   females/212	C3: 34% D2: 12%	.018	*	19.8	45	92889
Pulmonary   adenocarcinoma (incidental)	D6Mit198m	All/869	C: 23% B6: 13%	.007	*	68	140	NA

Notes: ^a Trait is the diagnosed cause of death, except for pulmonary adenocarcinoma, in which the trait was the presence of this lesion at necropsy, regardless of cause of death.

^bLocus indicates the SSLP marker most closely linked to the QTL. An “m” in the locus designation indicates maternal inheritance, and a “p” indicates paternal inheritance.

^cIndicates the group of mice evaluated (all mice, or just multiparous females), and the number of mice included in the calculation. Values of “N” differ slightly because the amount of missing genotype data varied among the SSLP marker loci.

^dGives the proportion of cases with indicated trait for each of the two relevant genetic alleles.

^e The permutation-based experiment-wise probability level for the association.

^fAn asterisk indicates those associations that reach the p <.05 significance criterion.

^g Pos (cM), Pos (mb), and MGI indicate, respectively, the position of the SSLP marker in centimorgans from the centromere, the position of the SSLP marker in millions of base pairs, and the identification code in the Mouse Genome Informatics database.

SSLP = simple sequence length polymorphism; NA = not available; QTL = quantitative trait locus.