. 2004 Jul 1;17(7):624–628. doi: 10.1016/j.amjhyper.2004.02.022

Table 3.

Genotype and allele frequencies of ACE2 polymorphisms in hypertensive (HT) and normotensive (NT) groups

Group	n	Genotype frequencies					Allele frequencies
Group	n	MM	Mm	mm	χ²	P	M	m	χ²	P
Intron 1 A→G variant
Female
NT	81	55 (0.68)	25 (0.31)	1 (0.01)	2.9	0.23	135 (0.83)	27 (0.17)	1.1	0.31
HT	78	50 (0.64)	23 (0.30)	5 (0.06)	2.9	0.23	123 (0.79)	33 (0.21)	1.1	0.31
Male
NT	96	—^*	—	—			68 (0.71)	28 (0.29)	0.28	0.60
HT	48	—	—	—			36 (0.75)	12 (0.25)	0.28	0.60
Intron 3 G→A variant
Female
NT	89	63 (0.71)	20 (0.22)	6 (0.07)	1.9	0.39	146 (0.82)	32 (0.18)	0.89	0.35
HT	65	40 (0.62)	21 (0.32)	4 (0.06)	1.9	0.39	101 (0.78)	29 (0.22)	0.89	0.35
Male
NT	104	—^*	—	—			83 (0.80)	21 (0.20)	0.52	0.47
HT	46	—	—	—			39 (0.85)	7 (0.15)	0.52	0.47
Intron 11 C→G variant
Female
NT	89	23 (0.26)	50 (0.56)	16 (0.18)	2.2	0.33	96 (0.54)	82 (0.46)	1.9	0.17
HT	100	34 (0.34)	54 (0.54)	12 (0.12)	2.2	0.33	122 (0.61)	78 (0.39)	1.9	0.17
Male
NT	89	—^*	—	—			62 (0.70)	27 (0.30)	0.0029	0.96
HT	52	—	—	—			36 (0.69)	16 (0.31)	0.0029	0.96
Intron 16 G→C variant
Female
NT	85	57 (0.67)	24 (0.28)	4 (0.05)	1.5	0.46	138 (0.81)	32 (0.19)	0.13	0.72
HT	91	62 (0.68)	21 (0.23)	8 (0.09)	1.5	0.46	145 (0.80)	37 (0.20)	0.13	0.72
Male
NT	103	—^*	—	—			85 (0.83)	18 (0.17)	0.0017	0.95
HT	47	—	—	—			39 (0.83)	8 (0.17)	0.0017	0.95

M = major allele, m = minor allele, of each polymorphism.

Values in parentheses are fractions.

As ACE2 is on the X chromosome (one copy), it is inappropriate to present genotype data.