Table 2:

Associations of PWV measures, derived CAVI, and derived CFVI with the risk of cardiovascular events

Characteristics		Q1		Q2	Q3		Q4
		HR (95% CI)	P*		HR (95% CI)	P*	HR (95% CI)	P*
Central arterial stiffness
cfPWV	Model 1	1.66 (0.96, 2.84)	0.07	ref	2.20 (1.31, 3.69)	0.003	2.54 (1.53, 4.21)	<0.001
	Model 2	1.80 (1.05, 3.10)	0.03	ref	2.01 (1.20, 3.39)	0.01	2.05 (1.23, 3.43)	0.01
	Model 3	2.03 (1.17, 3.50)	0.01	ref	2.02 (1.20, 3.41)	0.01	1.91 (1.13, 3.23)	0.02
	Model 4	1.97 (1.14, 3.39)	0.02	ref	1.96 (1.16, 3.31)	0.01	1.83 (1.08, 3.09)	0.02
hfPWV	Model 1	1.16 (0.71, 1.88)	0.56	ref	1.21 (0.75, 1.97)	0.44	1.74 (1.11, 2.73)	0.02
	Model 2	1.28 (0.78, 2.08)	0.33	ref	1.09 (0.67, 1.78)	0.72	1.37 (0.86, 2.18)	0.19
	Model 3	1.33 (0.81, 2.17)	0.26	ref	1.04 (0.63, 1.69)	0.89	1.26 (0.78, 2.03)	0.35
	Model 4	1.33 (0.81, 2.17)	0.26	ref	1.04 (0.64, 1.70)	0.87	1.19 (0.73, 1.93)	0.48
Derived CFVI	Model 1	1.38 (0.83, 2.28)	0.21	ref	1.49 (0.91, 2.46)	0.12	1.97 (1.23, 3.17)	0.01
	Model 2	1.46 (0.88, 2.41)	0.15	ref	1.29 (0.78, 2.13)	0.32	1.47 (0.90, 2.40)	0.13
	Model 3	1.51 (0.91, 2.50)	0.11	ref	1.25 (0.75, 2.07)	0.39	1.36 (0.83, 2.24)	0.22
	Model 4	1.51 (0.91, 2.51)	0.11	ref	1.24 (0.75, 2.06)	0.39	1.30 (0.79, 2.14)	0.30
Composite arterial stiffness
baPWV	Model 1	0.89 (0.54, 1.45)	0.63	ref	1.51 (0.98, 2.34)	0.06	1.45 (0.93, 2.25)	0.10
	Model 2	1.02 (0.62, 1.67)	0.94	ref	1.40 (0.90, 2.17)	0.13	1.21 (0.77, 1.90)	0.40
	Model 3	1.10 (0.67, 1.82)	0.70	ref	1.34 (0.86, 2.08)	0.19	1.13 (0.71, 1.81)	0.59
	Model 4	1.09 (0.66, 1.80)	0.73	ref	1.35 (0.87, 2.09)	0.18	1.12 (0.70, 1.78)	0.64
haPWV	Model 1	1.09 (0.67, 1.77)	0.73	ref	1.16 (0.72, 1.87)	0.55	1.52 (0.96, 2.40)	0.07
	Model 2	1.21 (0.75, 1.98)	0.44	ref	1.07 (0.66, 1.73)	0.79	1.21 (0.76, 1.92)	0.43
	Model 3	1.28 (0.78, 2.09)	0.33	ref	1.03 (0.63, 1.67)	0.91	1.14 (0.70, 1.85)	0.61
	Model 4	1.28 (0.78, 2.09)	0.33	ref	1.00 (0.62, 1.63)	0.99	1.10 (0.67, 1.80)	0.70
Derived CAVI	Model 1	1.07 (0.66, 1.74)	0.77	ref	1.30 (0.82, 2.07)	0.26	1.38 (0.87, 2.18)	0.17
	Model 2	1.12 (0.69, 1.81)	0.66	ref	1.10 (0.69, 1.75)	0.69	0.97 (0.60, 1.56)	0.89
	Model 3	1.13 (0.69, 1.84)	0.62	ref	1.08 (0.67, 1.72)	0.76	0.95 (0.59, 1.54)	0.84
	Model 4	1.12 (0.68, 1.82)	0.66	ref	1.07 (0.67, 1.72)	0.76	0.94 (0.58, 1.52)	0.80

Model 1: Crude

Model 2: Age, sex, race

Model 3: Model 2 + education, current smoking, body mass index, history of diabetes, mean arterial pressure, antihypertensive medication, total cholesterol, high-density lipoprotein

Model 4: Model 3 + ankle brachial index, estimated glomerular filtration rate, albumin-creatinine ratio

HR=hazard ratio; Q1, Q2, Q3, Q4=quartile 1, quartile 2, quartile 3, quartile 4

^*P-values test quartile-specific estimates vs. the referent (quartile 2)