Fig. 1.

The macro domain family. The structures of the macro domain proteins are depicted, showing the conserved macro domains, as well as other domains found in selected members of the family, such as the histone H2A domain; Lys-rich domain; Glu-rich domain; SEC14 domain, a lipid-binding domain found in SEC14p and other proteins; SNF2 domain, the SNF2 helicase-like domain; PARP domain, poly(ADP-ribose)polymerase domain; WWE domain, a protein–protein interaction domain containing conserved Trp and Glu residues; HLH domain, helix–loop–helix DNA binding domain; ZnF domain, ubiquitin-binding zinc finger domain. Please note that several members of the macroPARPs (PARP-9/BAL1; PARP-14/BAL2/CoaSt6; PARP-15/BAL3) display splicing variants, but for simplicity, only one variant is illustrated. Human macro domain proteins are presented on the left and homologues from other organisms are shown on the right, including macro domain proteins from Escherichia coli (E.c), Drosophila melanogaster (D), Xenopus laevis (X), viruses (V), Archaeoglobus fulgidus (A.F), Arabidopsis thaliana (A.t) and Oryza sativa (O.s). Numbers refer to amino acid positions in the proteins.