Table 1.
Characteristics of the Cohort of Transplanted Patients and Patients with VRIs per Groups: (1) AdV, (2) HCoV/HRV, and Influenza, PIVs, Human MPV, and RSV (Flu-Like)
| Characteristics | Whole Cohort | All VRI | AdV | HCoV/HRV | Flu-Like |
|---|---|---|---|---|---|
| Number of patients | 378 | 166 | 16 | 84 | 66 |
| Age at transplant, yr (range) | 43 (5-68) | 39 (9-66) | 28 (15-59) | 41 (9-66) | 40 (14-66) |
| Gender, n (%) | |||||
| Female | 140 (37) | 63 (38) | 5 (31) | 37 (44) | 21 (32) |
| Male | 238 (63) | 103 (62) | 11 (69) | 47 (56) | 45 (68) |
| Hematological disease, n (%) | |||||
| Malignancy | 326 (86.2) | 158 (95) | 16 (100) | 80 (95.2) | 62 (94) |
| Nonmalignancy | 52 (13.8) | 8 (5) | 0 | 4 (4.8) | 4 (6) |
| Stem cell source, n (%) | |||||
| Bone marrow | 82 (21.7) | 15 (9) | 1 (6) | 7 (8) | 7 (11) |
| Peripheral stem cells | 257 (68) | 141 (85) | 14 (88) | 71 (85) | 56 (85) |
| Cord blood | 39 (10.3) | 10 (6) | 1 (6) | 6 (7) | 3 (5) |
| Donor type, n (%) | |||||
| HLA-identical sibling | 181 (47.9) | 73 (44) | 6 (38) | 35 (52) | 32 (49) |
| HLA-matched unrelated | 128 (33.9) | 64 (39) | 7 (44) | 34 (40) | 23 (35) |
| HLA-mismatched unrelated | 69 (18.3) | 28 (17) | 3 (19) | 15 (18) | 10 (15) |
| Myeloablative conditioning regimen | 151 (39.9) | 37 (22) | 4 (25) | 21 (25) | 12 (18) |
| Median months from transplant to VRI (interquartile range) | 4 (2-7) | 4 (2-11) | 3 (1-5) | 4 (2-8) | |
| At time of VRI | |||||
| Active GVHD∗ | 38 (23) | 5 (31) | 21 (25) | 12 (18) | |
| Steroid dose ≥ 1 mg/kg/day | 37 (22) | 5 (31) | 18 (21) | 14 (21) | |
| Neutropenia <.5 g/L | 23 (14) | 6 (38) | 9 (11) | 8 (12) | |
| Lymphopenia <.5 g/L | 62 (38) | 9 (56) | 29 (35) | 24 (37) | |
| Pneumonia† | 55 (33) | 7 (44) | 26 (31) | 22 (33) | |
| Nosocomial VRI | 47 (28) | 7 (44) | 25 (30) | 15 (23) | |
| Copathogen‡ | 74 (45) | 12 (75) | 32 (38) | 30 (45) | |
| VRI outcome | |||||
| Hospitalization, n (%) | 51 (31) | 5 (31) | 22 (27) | 24 (36) | |
| Hypoxemia, n (%) | 17 (10) | 4 (25) | 5 (6) | 8 (12) | |
| Mechanical ventilation, n (%) | 3 (2) | 1 (6) | 1 (1) | 1 (2) | |
| Death within 3 mo, n (%) | 16 (10) | 3 (19) | 6 (7) | 7 (11) |
∗
Active GVHD was defined as GVHD not in partial or complete remission.
†
Pneumonia was defined as new pulmonary infiltrates on imagery.
‡
Copathogen was defined as a second infection including opportunistic (cytomegalovirus), bacterial, or fungal infection.