Fig. 5.

Comparative analysis of L1PA3 elements great apes. a Coverage tracks for all full length great ape L1PA3 elements mapped to the human consensus. All great apes exhibit a shared deletion, evidenced by a coverage drop over 129 bp. b Coverage map of gibbon L1PA4 elements (mapped to the L1PA5 consensus) demonstrates a different path of ZNF93 evasion (a 20 bp deletion). A second region near the major ZNF765 binding site (green) also demonstrates a coverage drop. c Analysis of mutational patterns in gibbon demonstrates that the 20 bp ZNF93-associated deletion likely occurred first in gibbon L1PA4 as most L1PA4s with ZNF765-associated deletions also contain a ZNF93-associated deletion