Table 3.
Factors associated with hospital mortality in study population (n = 2005) and in patients with hyperoxemia at day 1 (n = 607)
| Factor | Odds ratio (95% confidence interval) | p value |
|---|---|---|
| Study population (n = 2005)—model on 1360 patients | ||
| Age (year) | 1.022 (1.015; 1.030) | <.0001 |
| BMI (kg/m2) | 0.978 (0.962; 0.995) | 0.0098 |
| SOFA score—cardiovascular | 1.182 (1.096; 1.275) | <.0001 |
| SOFA score—respiratory | 1.405 (1.182; 1.669) | 0.0001 |
| SOFA score—renal | 1.209 (1.087; 1.344) | 0.0005 |
| SOFA score—central nervous system | 1.147 (1.061; 1.240) | 0.0006 |
| Active/hematologic neoplasm or immunosuppression (ref. no.) | 2.248 (1.697; 2.978) | <.0001 |
| Chronic liver failure (ref. no.) | 4.315 (2.184; 8.523) | <.0001 |
| PIP (cmH2O) | 1.030 (1.013; 1.046) | 0.0003 |
| Invasive mechanical ventilation (ref. no.) | 0.497 (0.339; 0.729) | 0.0004 |
| Bicarbonate (mmol/L) | 0.979 (0.960; 0.997) | 0.0240 |
| Patients with PaO2> 100 mmHg (n = 607)—model on 530 patients | ||
| Age (year) | 1.031 (1.018; 1.044) | <.0001 |
| SOFA score —renal | 1.362 (1.152; 1.610) | 0.0003 |
| SOFA score—cardiovascular | 1.205 (1.073; 1.352) | 0.0016 |
| Active/hematologic neoplasm or immunosuppression (ref. no) | 1.828 (1.186; 2.819) | 0.0063 |
| Chronic liver failure (ref. no.) | 4.091 (1.256; 13.328) | 0.0194 |
| Total respiratory rate (breath/min) | 1.043 (1.015; 1.072) | 0.0027 |
| Bicarbonate (mmol/L) | 0.958 (0.924; 0.994) | 0.0210 |
Abbreviations: BMI body mass index, PIP peak inspiratory pressure, SOFA sepsis-related organ failure assessment