Table 6.

ADME parameters of synthesized compounds

Comp.	ADME parameters
	Mol MW	Rule of Five	QPlogPo/w	Human Oral Absorption	Volume	% Human Oral Absorption	QPlogPw	QPlogKp	QPlogBB	Donor HB	Accept HB
1	308.354	0	3.38	3	957.885	100.0	8.709	− 1.987	− 0.778	1.0	4.0
2	247.271	0	0.656	3	743.851	67.916	11.506	− 4.204	− 1.339	3.0	5.0
3	323.369	0	2.789	3	999.18	91.672	11.575	− 2.168	− 1.011	2.0	5.5
4	342.799	0	3.817	3	995.909	100.0	8.468	− 2.092	− .0.613	1.0	4.0
5	342.799	0	3.871	3	1001.91	100.0	8.469	− 2.155	− 0.631	1.0	4.0
6	312.342	0	2.331	3	947.57	91.759	9.026	− 2.078	− 0.808	1.0	5.0
7	322.381	0	3.687	3	1017.578	100.0	8.404	− 2.183	− 0.813	1.0	4.0
8	322.381	0	3.688	3	1017.852	100.0	8.405	− 2.184	− 0.814	1.0	4.0
9	336.408	0	3.986	3	1072.652	100.0	8.091	− 2.333	− 0.807	1.0	4.0
10	336.408	0	3.958	3	1063.481	100.0	8.109	− 2.259	− 0.758	1.0	4.0
11	326.344	0	3.583	3	971.486	100.0	8.509	− 2.081	− 0.674	1.0	4.0
12	387.25	0	3.949	3	1010.987	100.0	8.477	− 2.157	− 0.622	1.0	4.0
13	353.352	0	2.681	3	1031.006	77.031	9.831	− 3.889	− 1.84	1.0	5.0
14	387.797	0	3.239	3	1073.076	82.122	9.524	− 3.85	− 1.579	1.0	5.0
15	338.38	0	3.509	3	1036.846	100.0	8.946	− 2.059	− 0.866	1.0	4.75
16	338.38	0	3.475	3	1032.883	100.0	8.937	− 2.085	− 0.869	1.0	4.75
17	338.38	0	3.477	3	1033.285	100.0	8.943	− 2.086	− 0.872	1.0	4.75
18	326.344	0	3.615	3	974.01	100.0	8.488	− 2.121	− 0.674	1.0	4.0
19	353.352	0	2.677	3	1030.425	77.006	9.824	− 3.892	− 1.835	1.0	5.0
20	400.578	0	5.921	1	1434.834	100.0	6.164	− 1.791	− 1.671	1.0	4.5