Table 2.

Treatment of Kawasaki disease (for detailed discussion of the treatment of Kawasaki disease see references5, 6, 97).

1. Intravenous immunoglobulin (IVIG)	At a dose of 2 g/kg given as a single infusion over 10–12 hours (unless cardiac status necessitates infusing the dose more slowly or in divided doses). Failure to respond to this initial IVIG dose is usually treated with a second dose (usually 2 g/kg as a single infusion). Failure to respond to the second IVIG dose is often treated with intravenous methylprednisolone under expert supervision
2. Aspirin	The dose of aspirin is controversial and its utility has never been proven in a randomised controlled trial. It remains, however, part of the standard management of KD. Generally ‘high dose’ aspirin (50–100 mg/kg/day in divided doses) is given acutely until the fever defervesces, when ‘low dose’ aspirin (2–5 mg/kg/day) is given until an echocardiogram at six weeks after the KD diagnosis is normal. If the six week echocardiogram is abnormal, aspirin is usually continued under cardiological supervision
3. Adjunctive therapies	Anti-cytokine therapies and other interventions are generally unproven but have occasionally been used. For a review see Newburger and Fullton5