Skip to main content
. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: J Med Chem. 2018 Dec 5;61(24):11341–11348. doi: 10.1021/acs.jmedchem.8b01580

Table 3.

The MICs of PTM derivatives 6a – 6t against S. aureus ATCC 29213, and several clinical MSSA and MRSA strains using agar dilution method (data from at least two independent experiments).

graphic file with name nihms-1579265-t0008.jpg
Compounds R group S. aureus ATCC MSSAs MRSAs
29213 1 2 3 4 5 6
PTM - 0.5 0.5 0.5 0.5 1 1 1
Linezolid - 1 1 1 1 1 1 1
6a -H 16 16 16 16 16 16 16
6b 2-OMe 8 8 16 16 16 16 16
6c 3,5-Cl 8 8 8 8 8 8 8
6d 3,5-Me 4 4 4 4 4 4 4
6e 2-Me 8 8 16 16 16 16 16
6f 3-Me 8 4 4 8 8 8 8
6g 4-Me 8 8 8 8 16 16 16
6h 2-Ph 4 8 8 8 8 8 8
6i 3-Ph 8 8 8 8 8 8 8
6j 4-Ph 4 8 8 8 8 8 8
6k 3-OH 32 32 32 32 32 32 32
6l 3-CF3 4 4 8 8 8 8 8
6m 3-OCF3 8 8 8 8 8 8 8
6n 4-nAmyl 4 4 4 4 4 4 4
6o 4-CHO 32 16 16 32 32 32 32
6p 4-Br 2 2 4 4 4 2 2
6q -H 8 8 8 8 8 8 8
6r -OEt 8 8 8 8 8 8 8
6s -Phenanthryl 2 2 2 4 2 4 2
6t -Pyrenyl 2 2 2 4 2 4 2