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Structure and Pharmacological Actions of Flavaglines
(A) Structure of selected natural (rocaglamide, rocaglaol, and silvestrol) and synthetic (FL3, FL40, and IMD-019064) flavaglines.
(B–E) Proposed models of the mode of action of flavaglines in cancer cells (B), lymphocytes (C), glial cells (D), and cardiomyocytes (E).
See also Figure S2, which illustrates the translocalization of PHB1 to mitochondria in noncancerous cells to promote survival.
