Table 1.
Proteins that Interact with PHBs
| Binding Partners | PHB | Biological Consequences | References |
|---|---|---|---|
| Mitochondrial Proteins | |||
| m-AAA protease | PHB1 | regulation of membrane protein degradation | Steglich et al., 1999 |
| ATAD3 | PHB1 | mitochondrial protein synthesis | He et al., 2012 |
| nucleoids (mitochondrial DNA associated to nucleoproteins) | PHB1/2 | maintenance of the organization and copy number of the mtDNA | Kasashima et al., 2008 |
| dynamin-like GTPase OPA-1 | PHB1 | stabilization of the structure of mitochondria during their fusion and morphogenesis | Merkwirth et al., 2008 |
| subunits of cytochrome c oxidase | PHB1 | function of the mitochondrial respiratory chain | Tsutsumi et al., 2009 |
| NADH-ubiquinone oxidoreductase 30 kDa subunit | PHB1 | stabilization of mitochondrial complex I | Park et al., 2010 |
| ND4 and ND5 | PHB1 | assembly of mitochondrial complex I | Bourges et al., 2004 |
| SLP-2 | PHB1/2 | stabilization of PHBs | Da et al., 2008 |
| TFAM | PHB1 | regulation of copy number of mitochondrial DNA | Kasashima et al., 2008 |
| ANT2 | PHB2 | unknown | Kasashima et al., 2006 |
| VDAC2 | PHB2 | unknown | Kasashima et al., 2006 |
| Hax-1 | PHB2 | stabilization of antiapoptotic Hax-1 | Kasashima et al., 2006 |
| nitric oxide-associated protein 1 (mNOA1) | PHB1 | regulation of mitochondrial protein translation and respiration | Heidler et al., 2011 |
| phosphorylated p66ShcA | PHB1 | putative protection against oxidative stress | Madireddi, 2006 |
| Transcription Factors | |||
| estrogen receptor | PHB1/2 | repression of estrogen-receptor activity | Delage-Mourroux et al., 2000; He et al., 2008; Montano et al., 1999 |
| E2Fs | PHB1 | repression of E2F activities | Gamble et al., 2007; Joshi et al., 2003, 2007; Schneider et al., 2010 |
| p53 | PHB1 | enhancement of p53-mediated transcriptional activity and chaperone activity of PHB1 for p53 | Chander et al., 2011; Fusaro et al., 2003; Joshi et al., 2007 |
| MyoD and MEF2 | PHB2 | repression of MyoD and MEF2 activities | Sun et al., 2004, 2011 |
| chicken ovalbumin upstream binding transcription factors I and II | PHB2 | transcriptional repression | Kurtev et al., 2004 |
| phosphorylated STAT3 | PHB1 | modulation of p53- and STAT3-mediated apoptosis | Kathiria et al., 2012b |
| Other Nuclear Proteins | |||
| HDAC1 and HDAC5 | PHB1/2 | transcriptional repression | Kurtev et al., 2004 |
| Rb and its family members p107 and p130 | PHB1 | repression of E2F-mediated transcription and inhibition of cell proliferation | Wang et al., 1999a, 1999b, 2002 |
| Brg-1 and Brm | PHB1 | repression of E2F-mediated transcription and inhibition of cell proliferation | Wang et al., 2002 |
| heterochromatin protein 1 (HP1) family proteins | PHB1 | repression of E2F-mediated transcription and induction of cellular senescence | Rastogi et al., 2006a |
| RING finger protein 2 (RNF2) | PHB1/2 | repression of the transcriptional activity of E2F1 and CP2c | Choi et al., 2008; Lee et al., 2008 |
| histone methyltransferase EZH2 | PHB2 | repression of estrogen-dependent transcription | Hwang et al., 2008 |
| PGC1α (PPARγ coactivator 1) | PHB2 | inhibition of the transcriptional activity of PPARγ | Endo, 2011 |
| minichromosomes maintenance complex of proteins MCM2, MCM5, and MCM 7 | PHB1 | inhibition of DNA replication | Rizwani et al., 2009 |
| nuclear receptor corepressor 1 (NCoR) | PHB1 | transcriptional repression of E2F family members | Wang et al., 2002 |
| Other Signaling Proteins | |||
| IgM receptor | PBH1 | phosphorylation of PHB1 | Terashima et al., 1994 |
| protease-activated receptor 1 | PHB1/2 | platelet aggregation | Zhang et al., 2012 |
| C-Raf | PBH1 | phosphorylation of C-Raf by Ras and consequently activation of the MEK-eIF4 pathway | Chiu et al., 2012; Chiu et al., 2013; Rajalingam et al., 2005 |
| Akt2 | PHB2 | cell-cycle exit and myogenic differentiation | Héron-Milhavet et al., 2008; Sun et al., 2004 |
| WD repeat domain 5 (WDR5, BIG3) | PHB2 | inhibition of the translocation of PHB2 to the nucleus | Kim et al., 2009 |
| Skp2B | PHB1/2 | attenuation of the transcriptional activity of p53, release of the repression of the estrogen receptor | Chander et al., 2010, 2011; Umanskaya et al., 2007 |
| MLK2 (mixed lineage kinase 2) | PHB1 | unknown | Rasmussen et al., 1998 |
| Shp1 (phosphatase) | phospho-Y114-PHB1 | modulation of insulin signaling | Ande et al., 2009a |
| PKC-δ | PHB1 | phosphorylation of PHB1 leading to a decrease in the inner mitochondrial membrane permeability and to cell survival | Zhu et al., 2010 |
| 14-3-3 protein | PHB1 | inhibition of PHB1 phosphorylation leading to an increase in the inner mitochondrial membrane permeability and to apoptosis | Zhu et al., 2010 |
| α-dystrobrevin | PHB1 | NB4 cell granulocytic differentiation | Borutinskaite et al., 2011 |
| transient Receptor Potential Melastatin 6 (TRPM6) | PHB2 | inhibition of TRPM6-mediated transepithelial Mg2+ transport | Cao et al., 2009 |
| HSP70 | PHB1 | resistance to stress | Liu et al., 2010 |
| glucose-regulated protein 75 (GRP75)/mortalin | PHB1 | cell proliferation, tumorigenesis and stress response in metastatic cells | Martín et al., 2008 |
| phospho- Ser291- Syk | PHB1 | B cell antigen-receptor signaling | Paris et al., 2010 |
| CRM-1 | PHB1 | export of PHB1 outside of the nucleus selectively in cancer cells | Rastogi et al., 2006b |
| Pex14p | PHB1 | regulation of the peroxisomal importomer | Oeljeklaus et al., 2012 |
| annexin A2 | PHB1/2 | interaction blocked by calcium, association with lipid rafts | Zhu et al., 2010 |
| alpha-actinin | PHB1/2 | interaction blocked by calcium, association with lipid rafts | Bacher et al., 2002 |
| EHD2 | Palmitoylated PHB1 | inhibition of pyruvate carboxylase leading to a decrease in glucose and fatty acid oxidation | Ande and Mishra, 2010; Vessal et al., 2006 |
| C3 | PHB1 | enhancement of innate immunity response | Mishra et al., 2007 |
| CK1ε | PHB2 | inhibition of circadian transcription | Kategaya et al., 2012 |
| Proteins of Pathogens | |||
| SV40Tag (viral oncoprotein) | PHB1 | interruption of the association between PHB1 and Brg-1/Brm | Wang et al., 2002 |
| HIV-1 glycoprotein | PHB1/2 | viral spread in nonpermissive cells | Emerson et al., 2010 |
| DENV-2 E protein | PHB2 | internalization of the dengue virus | Kuadkitkan et al., 2010 |
| Chikungunya virus E2 protein | PHB1 | internalization of the chikungunya virus | Wintachai et al., 2012 |
| SARS-CoV nonstructural protein nsp2 | PHB1/2 | supposed disruption of intracellular host signaling during SARS-CoV infection | Cornillez-Ty et al., 2009 |
| Vi polysaccharide of Salmonella typhi | PHB1/2 | inhibition of the inflammatory response upon infection with Vi- S. typhi. | Sharma and Qadri, 2004 |
| capsid protein VP1 of foot-and-mouth disease virus | PHB1 | dephosphorylation of PHB T258 | Chiu et al., 2012 |
| macrophage surface HSP70 | Leishmania donovani PHB1 | induction of a strong humoral response in leishmaniasis patients | Jain et al., 2010 |
See also Table S1.