Table 2.

Roles of PHB Signaling in Cancer

Antitumorigenic Roles of PHBs	References
PHB1 activates the tumor suppressor p53	Chander et al., 2011; Fusaro et al., 2003; Joshi et al., 2007
PHB1 interacts with the tumors suppressors Rb, p107, and p130 to repress E2F-mediated transcription and inhibit cell proliferation	Wang et al., 1999a, 1999b, 2002
PHB1 represses DNA replication by interacting with components of the mammalian replication machinery	Rizwani et al., 2009
Protumorigenic Roles of PHBs
PHB1 and PHB2 are necessary for the activation of C-RAF by Ras	Rajalingam et al., 2005
phosphorylated PHB1 promotes the survival of prostate cancer cells	Zhu et al., 2010
the oncomir miR-27a downregulates PHB1	Liu et al., 2010; Fletcher et al., 2012
localized on the cell surface, PHB1 mediates resistance to taxoids	Patel et al., 2010