Table 2.
Diagnostic values of DCP for AFP-negative HBV-related HCC.
| Groups compared |
DCP |
|||||
|---|---|---|---|---|---|---|
| Cutoff (mAU/mL) | AUC (95%CI) | Sen (%) | Spe (%) | PPV (%) | NPV (%) | |
| All HCC vs LC or CHB | 45 | 0.731 (0.657–0.805) | 50.6 | 94.3 | 86.3 | 73.0 |
| All HCC vs LC | 41 | 0.728 (0.649–0.806) | 50.6 | 91.7 | 88.0 | 60.6 |
| Early-stage HCC vs LC, CHB | 45 | 0.685 (0.596–0.774) | 43.5 | 94.3 | 79.4 | 76.8 |
| Early-stage HCC vs LC | 41 | 0.683 (0.591–0.775) | 43.5 | 91.7 | 81.8 | 65.3 |
HCC, hepatocellular carcinoma; LC, liver cirrhosis; CHB, chronic hepatitis B virus infection; DCP, des-γ-carboxy prothrombin; AUC, area under curve; Sen, sensitivity; Spe, specificity; PPV, positive predictive value; NPV, negative predictive value.