Table 1.

Descriptive statistics for serum calcium and serum PTH between heterozygotes versus homozygotes for CASR variant(s).^a,b,c

	Heterozygotes (Monoallelic) n = 21	Homozygotes (Biallelic) n = 36	P Value
Maximal calcium (mM)	3.20 ± 0.26 (3.08–3.32)	5.83 ± 1.54 (5.31–6.35)	< .001
Maximal PTH (ratio)	8.14 ± 8.98 (4.06–12.23)	17.42 ± 11.87 (13.41–21.44)	.003
Slope of maximal calcium (mM) versus maximal PTH (ratio)	-0.00238 ± 0.0300 (–0.01608 to +0.01132)	0.01413 ± 0.1326 (–0.03077 to +0.05903)	0.52
Maximal calcium at PTH = 0 (mM)	3.22 ± 0.36 (3.06–3.38)	5.58 ± 2.78 (4.64–6.53)	< .001

Data are mean ± standard deviation (and 95% confidence interval).

^aSerum calcium was scored as the maximal value for that case. Serum PTH was scored as the ratio of [maximal PTH] divided by [upper normal PTH].

^bFive compound heterozygotes are included within the homozygote group.

^cNormal ranges: calcium 2.2 to 2.6 mM; PTH ratio 0.3 to 1.0.

Abbreviation: PTH, parathyroid hormone.