Table 2.

Summary of the growth inhibitory potential (expressed as GI₅₀) of selected nucleoside analogs against the NCI-60 tumor cell line panel with Sulforhodamine B (SRB) read-out at 48 h [43,44]. Full details (GI₅₀ values for all cell lines) can be found in the Supporting Information. Values represent mean ± SEM of two independent evaluations.

Cpd	Leukemia			Lung		Colon
	CCRF-CEM GI50 (μM)	HL-60 GI50 (μM)	SR GI50 (μM)	A549 GI50 (μM)	NCI-H460 GI50 (μM)	HCT116 GI50 (μM)
31b	0.338	0.436	0.185	0.377	0.231	0.153
32	0.248 ± 0.009	0.059 ± 0.025	0.074 ± 0.013	0.188 ± 0.050	[<0.01–0.046]a	0.020 ± 0.002
33	0.213 ± 0.073	0.047 ± 0.025	0.064 ± 0.02	0.019 ± 0.097	0.034 ± 0.016	0.028 ± 0.002
34	0.272 ± 0.023	0.050 ± 0.018	0.28 ± 0.098	0.443 ± 0.146	0.098 ± 0.039	0.045 ± 0.01
37b	2.3	1.57	0.817	1.31	0.473	0.595

^aValues in brackets represent the obtained GI₅₀ values from both experiments.

^bCompounds 31 and 37 were only tested once.