Table 3.

Summary of the growth inhibitory potential (expressed as GI₅₀) of selected nucleoside analogs against the NCI-60 tumor cell line panel with Sulforhodamine B (SRB) read-out at 48 h [43,44]. Full details (GI₅₀ values for all cell lines) can be found in the Supporting Information. Values represent mean ± SEM of two independent evaluations.

Cpd	CNS	Melanoma	Prostate		Breast
	U251 GI50 (μM)	Lox IMVI GI50 (μM)	PC-3 GI50 (μM)	DU145 GI50 (μM)	MCF7 GI50 (μM)	MDA-MB-231 GI50 (μM)
31b	0.631	0.279	0.293	0.354	0.103	0.379
32	[<0.01–0.02]a	0.059 ± 0.023	0.192 ± 0.019	0.134 ± 0.025	0.027 ± 0.005	0.170 ± 0.02
33	0.022 ± 0.009	0.067 ± 0.038	0.107 ± 0.060	0.107 ± 0.044	0.023 ± 0007	0.136 ± 0.08
34	0.074 ± 0.006	0.060 ± 0.021	0.076 ± 0.010	0.131 ± 0.033	[<0.01–0.014]a	0.186 ± 0.02
37b	2.44	0.667	0.808	0.563	0.239	1.53

^aValues in brackets represent the obtained GI₅₀ values from both experiments.

^bCompounds 31 and 37 were only tested once.