Figure 3.

Complex Structure of NPC1-C Bound to GPcl

(A) The bound GPcl structure. The visible portions of GP1 and GP2 subunits are colored in green and yellow, respectively, and the other invisible or cleavage-removed portions are colored in gray.

(B) Overall complex structure. The NPC1-C uses its two protruding loops to bind to the head of GPcl at a perpendicular angle.

(C) Surface representations of interacting residues in the NPC1-C and GPcl. The residues responsible for the binding in the NPC1-C (top) are colored in blue, and the interacting residues in the GPcl (bottom) are colored in orange. The NPC1-C mainly utilizes aromatic residues to engage the cavity of the GPcl, which mainly consists of hydrophobic residues.

See also Table S1.