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. 2019 Apr 2;60:39–56. doi: 10.1016/j.cellsig.2019.03.024

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© 2019 Published by Elsevier Inc.

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Fig. 1 — Immunohistochemical analysis of IFITM1/3 protein expression in cervical cancers using the Mab-MHK. Formalin-fixed, paraffin-embedded cervical carcinoma tissue was processed as stated in the Experimental Procedures using the Mab-MHK that binds to shared epitopes in the N-terminal domains of IFITM1 and IFITM3 (Supplementary Fig. 1A, B). Representative images highlight grades of IFITM1/3 protein expression; (A). high expression in squamous cell carcinoma, (B). medium expression in squamous cell carcinoma, (C). absence of expression in squamous cell carcinoma, (D). high expression in adenocarcinoma, and (E). expression in basal stem cell layer in normal tissue. (F). (Top panel); Quantification of IFITM1/3 protein expression in cervical cancer in relation to histology type and (Bottom panel) IFITM1/3 protein expression in cervical cancer in relation to lymph node metastasis, excluding neuroendocrine. (G). Immunoblotting of protein expression in the parental SiHa cells after IFNγ treatment for the indicated time points. Proteins evaluated include; STAT1; β-actin, IRF1, and IFITM1/3.