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Effects of CI - 39, 6d, 10f, and 10i on HIV-1 RT DNA polymerase and ribonuclease H activities.
| Compd | IC50±SD, μM |
||
|---|---|---|---|
| DNA polymerase | Ribonuclease H | VSVG/HIV-1 replication | |
| CI - 39 | 7.20 ± 0.50 | >30 | 3.37 ± 0.45 |
| 6d | 0.27 ± 0.03 | >100 | 0.49 ± 0.11 |
| 10f | 0.11 ± 0.04 | >100 | 0.07 ± 0.02 |
| 10i | 0.08 ± 0.005 | >100 | 0.04 ± 0.01 |
| HQD | NT | 2.81 ± 0.15 | NT |
| NVP | 0.98 ± 0.53 | NT | 0.02 ± 0.003 |
| EFV | 0.01 ± 0.003 | NT | 0.001 ± 0.0001 |
IC50: half maximal inhibitory concentration; NT: not tested.
