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. 2018 Sep 11;143:52–66. doi: 10.1016/j.pbiomolbio.2018.08.009

Fig. 7.

Fig. 7

The isolated Dengue NS3 protease domain lacks the intrinsic capacity to fold into a chymotrypsin fold. Two-dimensional 1H-15N NMR HSQC spectra of the Dengue NS3 protease domain in the isolated state (A), and in complex with the NS2B cofactor (B). (C) Residue specific (ΔCα-ΔCβ) values of the NS3 protease domain in the isolated state obtained in our study (red), and in complex with NS2B (blue) previously published. (D) Residue-specific {1H}–15N heteronuclear steady-state NOE (hNOE) of the NS3 protease domain in the isolated state.