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The disordered Dengue NS3 protease domain has non-native long-range contacts. Intensity ratios of HSQC peaks and structures for the spin-labeled Q27C (A), E86C (B) and S158C (C) in the paramagnetic state of the MTSL probe and diamagnetic state after the MTSL probe was reduced. NS3 protease domains with the residue colored in green if its intensity ratio <0.85. (D) A proposed model for the co-folding of the NS2B-NS3 two-component protease.
