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. 2019 May 2;533:21–33. doi: 10.1016/j.virol.2019.05.001

Fig. 8.

Fig. 8

Superimposition of active-site residues of coronavirus and mesonivirus 3CLpros. Shown are the active sites of the 3CLpros of TGEV (Kim et al., 2012) (PDB ID: 4F49; light blue), IBV (Xue et al., 2008) (PDB ID: 2Q6D; pink), SARS-CoV (Zhu et al., 2011) (PDB ID: 3SNE; yellow), HCoV-HKU1 (Zhao et al., 2008) (PDB ID: 3D23; dark blue), and CavV (PDB ID: 5LAK; green). All structures are represented as sticks and color-coded by atom types. Water molecules of 4F49, 2Q6D, 3SNE and 3D23 are represented as red spheres and water molecules of 5LAK are represented as green spheres. (a) superimposition of 4F49, 2Q6D, 3SNE, and 3D23; (b) superimposition of the coronavirus 3CLpro active sites shown in panel (a) (PDB ID: 4F49, 2Q6D, 3SNE, and 3D23) with the CavV 3CLpro active site (PDB ID: 5LAK); (c) active site of the CavV 3CLpro alone (PDB ID: 5LAK).